Funding for this research was provided by:
First Online: 17 June 2020
Compliance with ethical standards
: Christi M.J. Steendam reports grants from Roche, outside the submitted work; Anne-Marie C. Dingemans attended advisory boards and/or provided lectures for Roche, outside the submitted work (paid to institution); Teun van Gelder has received consulting fees from Roche Diagnostics, outside the submitted work; and Ron H.J. Mathijssen reports grants from Roche, outside the submitted work (paid to institution). G.D. Marijn Veerman, Koen G.A.M. Hussaarts, Robert Peric, Esther Oomen-de Hoop, Kersten D. Landa, Cor H. van der Leest, Suzanna D. Broerse, Hugo B. Rutten, Huub N.A. Belderbos, Marthe S. Paats, Stijn L.W. Koolen, Roelof W.F. van Leeuwen and Joachim G.J.V. Aerts declare no competing interests. (Part of) this work was presented at ESMO 2019 as a poster presentation (#1540P).
: This study was approved by the local Ethics Committee (Erasmus University Medical Center Rotterdam; MEC 16–590) and was registered in the Dutch Trial Registry (number NL5984; NTR6148).
: All participating patients were asked to sign a written informed consent form.