Berger, Benjamin http://orcid.org/0000-0001-7777-5734
Dingemanse, Jasper http://orcid.org/0000-0002-4083-5817
Sabattini, Giancarlo
Delahaye, Stéphane
Duthaler, Urs http://orcid.org/0000-0002-7811-3932
Muehlan, Clemens http://orcid.org/0000-0002-0788-3788
Krähenbühl, Stephan http://orcid.org/0000-0001-8347-4145
Article History
Accepted: 12 April 2021
First Online: 18 May 2021
Declarations
:
: The study was sponsored by Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
: Benjamin Berger, Jasper Dingemanse, Giancarlo Sabattini, Stéphane Delahaye, and Clemens Muehlan were full-time employees of Idorsia Pharmaceuticals Ltd during the conduct of the study. Jasper Dingemanse, Stéphane Delahaye, and Clemens Muehlan own stocks (options) of Idorsia Pharmaceuticals Ltd. Urs Duthaler and Stephan Krähenbühl were employees of the University Hospital Basel (Division of Clinical Pharmacology and Toxicology) and, in addition, Urs Duthaler was also employed by the University of Basel (Department of Biomedicine) during the conduct of the study. There are no other relationships or activities that could appear to have influenced the submitted work. The University Hospital Basel (Division of Clinical Pharmacology and Toxicology) received financial compensation for the clinical conduct.
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
: Informed consent was obtained from all individual participants included in the study prior to any study-mandated procedure.
: Not available.
: The data that support the findings of this study are available from the corresponding author, upon reasonable request.
: Not applicable.
: JD and CM designed the study. UD and SK performed the assessments and collected the data. Data were analyzed by BB, JD, GS, SD, UD, CM, and SK. BB, JD, and SK wrote the manuscript. All authors reviewed and approved the final manuscript. The authors confirm that the principal investigator for this paper is SK and that he had direct clinical responsibility for the subjects.