Sten, Sebastian http://orcid.org/0009-0009-7339-6708
Cardilin, Tim http://orcid.org/0009-0008-5167-5055
Antonsson, Madeleine http://orcid.org/0000-0001-8734-7549
Gennemark, Peter http://orcid.org/0000-0002-7865-7454
Article History
Accepted: 22 September 2023
First Online: 12 October 2023
Declarations
:
: No external funding was used in the preparation of this paper.
: Sebastian Sten, Madeleine Antonsson, and Peter Gennemark are employed by AstraZeneca. Tim Cardilin declares that he has no potential conflicts of interest that might be relevant to the contents of this paper.
: Not applicable.
: Not applicable.
: Not applicable.
: All data generated or analyzed during this study are included in this published article (and its ESM files).
: The complete code for the PBPK model is available in the ESM.
: Tim Cardilin collected the data and implemented the PBPK model. Sebastian Sten, Tim Cardilin and Peter Gennemark analyzed and interpreted the data. Sebastian Sten and Peter Gennemark drafted the paper. All authors were involved in critical revisions of the paper for important intellectual content, and in the approval of the final version.