Updates are available Correction dated 2018-04-10

Article History

First Online: 12 March 2018

Compliance with Ethical Standards

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: Adamas Pharmaceuticals, Inc. funded these studies and analyses. Editorial assistance to the authors was provided by The Curry Rockefeller Group, LLC, and this assistance was funded by Adamas. Open access was funded by Adamas.

: Lawrence W. Elmer has received honoraria for speaking engagements from Lundbeck, Novartis, UCB Pharma, and Teva Neuroscience; has served as a paid consultant for Teva Neuroscience and UCB Pharma; has received honoraria as a member of advisory boards for Lundbeck, Teva Neuroscience, and UCB Pharma; and has received unrestricted educational grant support from Teva Neuroscience. Jorge L. Juncos reports research grants from the National Institute of Child Health and Human Development (NICHD), the Michael J. Fox Foundation, Adamas Pharmaceuticals, US WorldMeds, Psydon, and Neurocrine. Carlos Singer has received honoraria from Neurocrine, Revance, US WorldMeds, TEVA, and Acorda, and has received grants from Allergan, Adams, Pfizer, Synovia, the Parkinson’s Foundation, National Institutes of Health (NIH), and the Huntington’s Disease Society of America. Daniel D. Truong has received research grants from Ispen, Merz, Auspex, Daiichi Sankyo Pharma, AbbVie, National Institute of Neurological Disorders and Stroke, Kyowa, and Neurocrine. Susan R. Criswell has no relevant disclosures or conflicts of interest. Sotirios Parashos has no relevant disclosures or conflicts of interest. Unrelated to the subject matter of this study, Sotirios Parashos has received consultancies from Dong-A, research support from the Park Nicollet Foundation, National Parkinson Foundation, NINDS, Patient-Centered Outcomes Research Institute, Acorda Therapeutics, Astellas, Pharma2B, and Sunovion Pharmaceuticals. Larissa Felt, Reed Johnson, and Rajiv Patni are employees of and own stock in Adamas Pharmaceuticals.