Morton, Emma http://orcid.org/0000-0001-6179-1983
Bhat, Venkat
Giacobbe, Peter
Lou, Wendy
Michalak, Erin E.
McInerney, Shane
Chakrabarty, Trisha
Frey, Benicio N.
Milev, Roumen V.
Müller, Daniel J.
Parikh, Sagar V.
Rotzinger, Susan
Kennedy, Sidney H.
Lam, Raymond W.
,
Funding for this research was provided by:
Ontario Brain Institute
Lundbeck
Bristol-Myers Squibb Canada
Servier
Article History
Accepted: 6 March 2021
First Online: 16 April 2021
Declarations
:
: EM conceptualized and conducted the statistical analysis and drafted the manuscript. SHK, RWL, RVM, SR, PG, SM, BNF, SVP, DJM, VB, WL, EEM, and TC made substantial contributions to overall study conception and design and to ongoing data collection and analysis. All authors provided critical revision of the manuscript for important intellectual content. All authors read and approved the final manuscript.
: CAN-BIND is an Integrated Discovery Programme that is carried out in partnership with, and receives financial support from, the Ontario Brain Institute, an independent non-profit corporation funded partially by the Ontario government. The opinions, results and conclusions are those of the authors, and no endorsement by the Ontario Brain Institute is intended or should be inferred. Additional funding was provided by the Canadian Institutes of Health Research, Lundbeck, Bristol Myers Squibb, and Servier. Funding and/or in-kind support was also provided by the investigators’ academic institutions. Emma Morton was supported by a postdoctoral award from the Marshall Scholars and Fellows Programme in Mental Health, Institute of Mental Health, University of British Columbia, Canada. Venkat Bhat was supported by an Academic Scholar Award from the Department of Psychiatry at the University of Toronto.
: Emma Morton, Venkat Bhat, Wendy Lou, Trisha Chakrabarty, and Daniel J. Müller have no conflicts of interest that are directly relevant to the content of this article. Peter Giacobbe has received research support from the Academic Scholar’s Award, University of Toronto Department of Psychiatry, CIHR, PSI, and Veteran's Affairs Canada; served on an advisory board for Janssen; and been an unpaid consultant for St. Jude Medical. Erin E. Michalak has received funding from Otsuka to support patient education initiatives. Shane McInerney has received advisory panel income from Janssen and research grant funding through the Healthy Minds Canada/Pfizer Canada Workplace Depression Awards. Benicio N. Frey has received a research grant from Pfizer outside of this work. Roumen V. Milev has received consulting and speaking honoraria from AbbVie, Allergan, Janssen, KYE, Lundbeck, Otsuka, and Sunovion and research grants from CAN-BIND, CIHR, Janssen, Lallemand, Lundbeck, Nubiyota, OBI, and OMHF. Sagar V. Parikh has received honoraria or research funds from Assurex, Takeda, Janssen, Mensante, Aifred, and Sage. Susan Rotzinger holds a patent ‘Teneurin C-Terminal Associated Peptides (TCAP) and methods and uses thereof.’ (inventors: David Lovejoy, R.B. Chewpoy, Dalia Barsyte, and Susan Rotzinger). Sidney H. Kennedy has received honoraria or research funds from Abbott, Alkermes, Allergan, Boehringer Ingelheim, Brain Canada, CIHR, Janssen, Lundbeck, Lundbeck Institute, Ontario Brain Institute, Ontario Research Fund, Otsuka, Pfizer, Servier, Sunovion, and Sun Pharmaceuticals and holds stock in Field Trip Health. Raymond W. Lam has received honoraria or research funds from Allergan, Asia-Pacific Economic Cooperation, BC Leading Edge Foundation, CIHR, CANMAT, Canadian Psychiatric Association, Hansoh, Healthy Minds Canada, Janssen, Lundbeck, Lundbeck Institute, MITACS, Myriad Neuroscience, Ontario Brain Institute, Otsuka, Pfizer, St. Jude Medical, University Health Network Foundation, and the VGH-UBC Hospital Foundation.
: The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.
: All participants provided written, informed consent.
: Data are not publicly available in accordance with ethics approval given by the ethics board from the participating university. Interested investigators may submit inquiries to the corresponding author.