Gao, Le http://orcid.org/0000-0002-9349-6599
Man, Kenneth K. C. http://orcid.org/0000-0001-8645-1942
Chan, Esther W. http://orcid.org/0000-0002-7602-9470
Chui, Celine S. L. http://orcid.org/0000-0003-1513-8726
Li, Xue http://orcid.org/0000-0003-4836-7808
Coghill, David http://orcid.org/0000-0003-3017-9737
Hon, Kam Lun http://orcid.org/0000-0002-6682-5529
Tse, Man Li http://orcid.org/0000-0003-2456-409X
Lum, Terry Y. S. http://orcid.org/0000-0003-1196-5345
Wong, Kirstie H. T. W. http://orcid.org/0000-0003-4374-490X
Ip, Patrick http://orcid.org/0000-0002-6797-6898
Wong, Ian C. K. http://orcid.org/0000-0001-8242-0014
Funding for this research was provided by:
Hong Kong Research Grants Council General Research Fund (17125419)
Article History
Accepted: 3 May 2021
First Online: 20 July 2021
Declarations
:
: This work was supported by Hong Kong Research Grants Council General Research Fund (No. 17125419) to Kenneth K.C. Man, Esther W. Chan, Celine S.L. Chui, David Coghill, Kam Lun Hon, Man Li Tse, Patrick Ip, and Ian C.K. Wong. The University of Hong Kong provided funding for open access.
: Le Gao, Kam Lun Hon, Man Li Tse, Terry Y.S. Lum, and Kirstie H.T.W. Wong declare no conflict of interest; Kenneth K.C. Man is the recipient of the CW Maplethorpe Fellowship, and reports grants from the National Institute for Health Research, UK, the Research Grant Council, Hong Kong, and personal fees from IQVIA Ltd., outside the submitted work; Esther W. Chan has received honorarium from the Hospital Authority, research grants from the Narcotics Division of the Security Bureau of HKSAR, National Health and Medical Research Council (NHMRC, Australia), National Natural Science Foundation of China (NSFC), Research Fund Secretariat of the Food and Health Bureau (HMRF, HKSAR), Research Grants Council (RGC, HKSAR), Wellcome Trust, Amgen, AstraZeneca, Bayer, Bristol-Myers Squibb, Janssen, Pfizer, RGA and Takeda, outside the submitted work; Celine S.L. Chui reports grants from Pfizer and personal fees from Primevigilance, outside the submitted work; Xue Li reports grants from Health and Medical Research Fund (HMRF), Janssen and an internal Seed Fund from the University of Hong Kong, outside the submitted work; David Coghill reports grants and personal fees from Shire/Takeda, personal fees from Medice, personal fees from Servier, personal fees from Oxford University Press, outside the submitted work; Patrick Ip reports research grants from the Hong Kong Research Grant Council (RGC) and Health and Medical Research Fund (HMRF), outside the submitted work; Ian C.K. Wong reports research funding outside the submitted work from Amgen, Bristol-Myers Squibb, Pfizer, Janssen, Bayer, GSK, Novartis, the Hong Kong RGC and the Hong Kong Health and Medical Research Fund, National Institute for Health Research in England, European Commission, National Health and Medical Research Council in Australia, and also received speaker fees from Janssen and Medice in the previous 3 years.
: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
: Same as data availability.
: This study was approved by the Institutional Review Board of the University of Hong Kong/Hospital Authority Hong Kong West Cluster (Reference No. UW 12-136).
: Not applicable.
: Not applicable.
: LG carried out the initial data analyses, drafted the initial manuscript, and had full access to the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis; KKCM designed and conceptualized the study, cross-checked the analysis, reviewed the manuscript and had full access to the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis; KHTW drafted the manuscript; EWC, CSLC, XL, DC, KLH, MLT and TYSL conceptualized the study, and critically reviewed the manuscript for important intellectual content; PI designed and conceptualized the study, coordinated and supervised data collection, and reviewed the manuscript; ICKW designed and conceptualized the study, coordinated and supervised data collection, reviewed the manuscript, and had full access to the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis; All authors were involved in the acquisition, statistical analysis, or interpretation of data. All authors critically revised the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.