Funding for this research was provided by:
Accepted: 31 August 2022
First Online: 23 September 2022
: This study was funded by Amgen Inc.
: Rebecca Persson received research grants to her institution from Amgen Inc. Myriam Cordey and Maria Paris are employees of Amgen Inc. Susan Jick received research grants to her institution and is a consultant for Amgen Inc.
: This study is based in part on data from the CPRD obtained under license from the UK Medicines and Healthcare products Regulatory Agency. The data are provided by patients and collected by the National Health Service as part of their care and support. The interpretation and conclusions contained in this study are those of the authors alone. This study was approved by the Independent Scientific Advisory Committee for Medicines and Healthcare products Regulatory Agency database research (protocol no.: 16_083) and registered in the European Union Post-Authorization Studies register (EUPAS11891). The protocol can be made available to the journal’s reviewers upon request. Hospital Episode Statistics Copyright © (2020), re-used with the permission of The Health and Social Care Information Centre. All rights reserved.
: Not applicable.
: Not applicable.
: Per our license agreement with CPRD, we cannot make data available. Requests to access data can be made directly to the CPRD.
: Raw CPRD data were accessed using the custom Delphi code. Datasets were analyzed using Stata version 15.
: All named authors meet the International Committee of Medical Journal Editors criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Author contributions were as follows: RP (design, electronic record review, analysis, interpretation, manuscript writing, manuscript revision), MC (interpretation, manuscript writing, manuscript revision), MP (design, interpretation, manuscript writing, manuscript revision), SJ (conception, design, electronic record review, acquisition, interpretation, manuscript writing, manuscript revision).