Text and Data Mining valid from 2018-02-23
First Online: 23 February 2018
Compliance with Ethical Standards
: The preparation of this review was not supported by any external funding.
: During the peer review process, both Merck and Pfizer were offered an opportunity to comment on the article. Changes resulting from any comments received were made by the author on the basis of scientific completeness and accuracy. A. Markham is a contracted employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest.Additional information about this Adis Drug Review can be found at ExternalRef removed.