First Online: 31 May 2018
Compliance with Ethical Standards
: All studies were sponsored and funded by AstraZeneca. David Candlish, of InScience Communications, Tattenhall, UK, provided editorial and medical writing assistance, which was funded by AstraZeneca.
: All authors are full-time permanent employees of AstraZeneca.
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
: Informed consent was obtained from all individual participants included in the studies.