Matcha, Saikumar
Dillibatcha, Jayashree
Raju, Arun Prasath
Chaudhari, Bhim Bahadur
Moorkoth, Sudheer
Lewis, Leslie E.
Mallayasamy, Surulivelrajan http://orcid.org/0000-0003-2568-5096
Funding for this research was provided by:
Indian Council of Medical Research (5/7/1694/CH/Adhoc/RBMCH-2020)
Manipal Academy of Higher Education, Manipal
Article History
Accepted: 20 February 2023
First Online: 21 March 2023
Declarations
:
: This work was supported by the Indian Council of Medical Research, grant number 5/7/1694/CH/Adhoc/RBMCH-2020. Surulivelrajan Mallayasamy is the principal investigator.
: Saikumar Matcha, Jayashree Dillibatcha, Arun Prasath Raju, Bhim Bahadur Chaudhari, Sudheer Moorkoth, Leslie E. Lewis, and Surulivelrajan Mallayasamy have no conflicts of interest that are directly relevant to the content of this article.
: The prospective longitudinal observational study was approved by Kasturba Medical College and Kasturba Hospital Institutional Ethics Committee, Manipal, India. (IEC-558/2019). We confirm that the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
: Neonates were recruited into the study after obtaining consent from their parents/guardians.
: Not applicable.
: Data are available from the corresponding author upon reasonable request.
: This work has used the PUMAS-AI software, the code is available from the corresponding author on request.
: Surulivelrajan Mallayasamy (SRM) and Lesli E. Lewis (LL) designed the protocol for the project. SRM took the responsibility to acquire funds for the research. Saikumar Matcha (SM) and Bhim Bahadur Chaudhari (BC) initiated the work. SM lead the patient recruitment along with BC. BC initiated the bioanalytical method development using the liquid chromatography with tandem mass spectrometry method under the supervision of Sudheer Moorkoth (SUM). BC and SM carried out the quantification of amikacin from plasma samples, SUM provided critical inputs for smooth conduction of the work. Jayashree Dillibatcha (JD) and Arun Prasath Raju (AR) along with SM contributed to analyze the predictive performance of published models of amikacin under the guidance of SRM. SM, JD, and AR developed the dosing nomogram under the supervision of SRM and LL. SM initiated the manuscript writing along with JD, AR, and BC. SRM, LL, and SUM provided the intellectual inputs. All the authors read and approved the final version of the manuscript.