Updates are available Correction dated 2021-06-19

Article History

Accepted: 30 March 2021

First Online: 26 April 2021

Change Date: 19 June 2021

Change Type: Correction

Change Details: A Correction to this paper has been published:

Change Details: https://doi.org/10.1007/s40273-021-01057-y

Declarations

:

: This project was funded by the NIHR Health Technology Assessment Programme (11/92/03) and supported by the NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust. The NIHR had no role in the design or conduct of this research.

: Sobha Sivaprasad reports grants and personal fees from Bayer, grants and personal fees from Novartis, grants and personal fees from Boehringer Ingleheim, grants and personal fees from Roche, and personal fees and non-financial support from Optos, outside the submitted work. Andrew Lotery reports personal fees from Novartis and non-financial support from Bayer, outside the submitted work. Michael Williams reports speaker fees and travel grants from Allergan, Bayer and Novartis. Andrew Metry reports grants from the NIHR Health Technology Assessment Grants Programme during the conduct of the study. Philip Hykin reports grants from NIHR Health Technology Assessment Programme (11/92/03) during the conduct of the study; grants, personal fees and non-financial support from BAYER, grants, personal fees and non-financial support from NOVARTIS, and grants, personal fees and non-financial support from Allergan, outside the submitted work. A. Toby Prevost reports personal fees from Bayer and grants from Boehinger-Ingleheim, outside the submitted work. Yit Yang reports personal fees and non-financial support from Novartis, personal fees and non-financial support from Bayer, personal fees and non-financial support from Allergan and personal fees and non-financial support from Roche, outside the submitted work. Becky Pennington, Abualbishr Alshreef, Laura Flight, Edith Poku, Joana C. Vasconcelos, Caroline Murphy, Joanna Kelly and John Brazier have no conflicts of interest that are directly relevant to the content of this article.

: The study was approved by the National Research Ethics Committee Service, London South East (14/LO/1043). Clinical Trials Authorisation was given by the Medicines and Healthcare Products Regulatory Agency (11412/0220/001-0005) and the European Union Drug Regulating Authorities Clinical Trials (EudraCT) number was 2013-003272-12. The study was conducted according to the principles of the Declaration of Helsinki.

: All patients signed informed consent.

: Not applicable.

: Summary-level data are available from the LEAVO study. Model input data are provided in the article and Appendix in the ESM. Patient-level data from LEAVO are not publicly available.

: Not applicable.

: Becky Pennington, Abualbishr Alshreef, Laura Flight, Philip Hykin, Sobha Sivaprasad, A. Toby Prevost, Joana C. Vasconcelos, Andrew Lotery and Michael Williams contributed to the research design, data acquisition and/or research execution, data analysis and/or interpretation and manuscript preparation. Andrew Metry contributed to data acquisition and/or research execution, data analysis and/or interpretation and manuscript preparation. Edith Poku contributed to the research design, data acquisition and/or research execution, data analysis and/or interpretation. Caroline Murphy and Joanna Kelly contributed to data acquisition and/or research execution. Yit Yang contributed to data acquisition and/or research execution and manuscript preparation. John Brazier contributed to the research design, data analysis and/or interpretation and manuscript preparation.