Mfumbilwa, Zakile A. http://orcid.org/0000-0002-9705-7227
Simons, Martijn J. H. G. http://orcid.org/0000-0001-5248-1676
Ramaekers, Bram http://orcid.org/0000-0001-5785-9228
Retèl, Valesca P. http://orcid.org/0000-0002-5624-3234
Mankor, Joanne M. http://orcid.org/0000-0003-3653-9043
Groen, Harry J. M. http://orcid.org/0000-0002-2978-5265
Aerts, Joachim G. J. V. http://orcid.org/0000-0001-6662-2951
Joore, Manuela http://orcid.org/0000-0002-5649-6768
Wilschut, Janneke A. http://orcid.org/0000-0002-4921-227X
Coupé, Veerle M. H. http://orcid.org/0000-0002-9553-9791
Funding for this research was provided by:
ZonMw (846001002)
KWF Kankerbestrijding
Achmea
Article History
Accepted: 6 December 2023
First Online: 9 January 2024
Declarations
:
: This work was funded by the Netherlands Organization for Health Research and Development (ZonMw) [Grant number 846001002], the Dutch Cancer Society (KWF), and the Dutch healthcare insurance company Zilveren kruis Achmea. The funding sources had no involvement in the conduct of this research. The Open Access Fee was paid by the Department of Epidemiology and Data Science, Amsterdam University Medical Centers.
: Joachim G.J.V. Aerts reports personal fees and non-financial support from MSD, personal fees from BMS, personal fees from Boehringer Ingelheim, personal fees from Amphera, personal fees from Eli-Lilly, personal fees from Takeda, personal fees from Bayer, personal fees from Roche, and personal fees from Astra Zeneca, outside the submitted work. In addition, Joachim G.J.V. Aerts has a patent allogenic tumor cell lysate licensed to Amphera, a patent combination immunotherapy in cancer pending, and a patent biomarker for immunotherapy pending. Zakile A. Mfumbilwa, Martijn J.H.G. Simons, Bram Ramaekers, Valesca P. Retèl, Joanne M. Mankor, Harry J.M. Groen, Manuela Joore, Janneke A. Wilschut, and Veerle M.H. Coupé have no conflicts of interest that are directly relevant to the content of this article.
: All methods were carried out in accordance with relevant guidelines and regulations. The study was performed in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
: Not applicable.
: Not applicable.
: All data generated or analyzed during this study are included in this article and its supplementary materials.
: The codes for the decision model are available on request. Request should be addressed to the corresponding author.
: ZAM: study conception and design, methodology, performed the analysis, data interpretation, writing main manuscript, review and editing. JAW and VMHC: study conception and design, methodology, data interpretation, writing main manuscript, review, editing, and study supervision. MJHGS, BR, VPR, and MJ: study conception and design, methodology, data interpretation, writing review and editing. JMM and JGJVA: study conception, validation of model assumptions and data, data interpretation and giving clinical contents, writing review and editing. HJMG: validation of model assumptions and data, data interpretation and giving clinical contents, writing review and editing. All authors reviewed the manuscript.