Funding for this research was provided by:
Fundação para a Ciência e a Tecnologia (HMSP/ICJ/0020/2011, UID/PSI/00050/2013)
Fundação Bial (176/10)
Received: 7 May 2016
Accepted: 15 December 2016
First Online: 18 January 2017
Compliance with ethical standards
: This work was supported by Fundação para a Ciência e Tecnologia through a Junior Research and Career Development Award from the Harvard Medical Portugal Program (HMSP/ICJ/0020/2011) to AJO-M and CPUP (UID/PSI/00050/2013) to ST, and a Grant from the BIAL Foundation (176/10) to AJO-M.
: On behalf of all authors, the corresponding author states that there is no conflict of interest.
: All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
: Informed consent was obtained from all individual participants included in the study.