Ghanbarian, Shahzad http://orcid.org/0000-0003-1882-8132
Wong, Gavin W. K.
Bunka, Mary
Edwards, Louisa
Cressman, Sonya
Conte, Tania
Peterson, Sandra
Vijh, Rohit
Price, Morgan
Schuetz, Christian
Erickson, David
Riches, Linda
Landry, Ginny
McGrail, Kim
Austin, Jehannine
Bryan, Stirling
Funding for this research was provided by:
Genome British Columbia (B26PMH)
Genome Canada (B26PMH)
Michael Smith Health Research BC (18932)
Article History
Accepted: 25 February 2024
First Online: 26 March 2024
Declarations
:
: The Pharmacogenomics for Depression project was funded by Genome BC and Genome Canada (project # B26PMH), and Michael Smith Health Research BC (award #18932).
: Christian Schuetz reports research funding from the Provincial Health Service Authority, Health Canada, Canadian Institutes of Health Research, Canadian Centre on Substance Use and Addiction (CCSA) and Clairvoyant; consulting fees from CCSA; and travel support from Suchtmedizin. He is chair of the addiction and psychosis committee of the International Society of Addiction Medicine; research lead, Mental Health and Addiction to the Provincial Health Services Authority; division head, Substance Use, and Concurrent Disorders with the University of British Columbia; and sits on the scientific committee of the World Association on Dual Disorders. Moreover, he serves on the scientific board of Clearmind. Jehannine Austin is vice president of the International Society for Psychiatric Genetics and associate editor with the Journal of Genetic Counseling. No other competing interests were declared.
: This project was approved by the University of British Columbia Clinical Research Ethics Board (#H20-02362).
: Not applicable.
: Not applicable.
: The main input parameters can be found in the electronic supplementary material (Appendices A–J), where detailed information regarding the data used in the study is reported. However, the resources from which these parameters were derived have been cited as references throughout the document to ensure accuracy and reliability.
: The code may be made available by the corresponding author, upon reasonable request.
: The authors of this study meet the authorship criteria outlined by the International Committee of Medical Journal Editors (ICMJE). JA and SB designed the original research question. SG developed, programmed, validated, and analyzed the discrete-time microsimulation model. GW and MB conducted a rapid literature review, sourced relevant literature, and performed meta-analyses to provide input parameters for the model. They also assisted with model validation checks. SC and TC contributed cost inputs for the model, while RV and SP, under the guidance of KM, prepared and analyzed administrative data for the model. MP, CS, and DE provided clinical expert opinions in cases where estimates from the literature were not available. GW, MB, MP, CS, DE, GL, LR, RV, LE, and SB reviewed and verified model assumptions. LR and GL ensured that the clinical pathway reflected real-world patient experiences. SG drafted the manuscript, which LE, SB, JA, and GW subsequently revised. All authors have thoroughly reviewed and approved the final manuscript for publication.