Buchalska, Barbara
Kamińska, Katarzyna http://orcid.org/0000-0002-7936-9374
Owe-Larsson, Maja
Cudnoch-Jędrzejewska, Agnieszka
Article History
Received: 28 December 2023
Revised: 16 February 2024
Accepted: 22 February 2024
First Online: 8 March 2024
Declarations
:
: Not applicable.
: The manuscript does not contain clinical studies or patient data.
: Authors declare no conflict of interests.
: ADC—apparent diffusion coefficient.AEA—anandamide.2-AG—2-arachidonoyl glycerol.Aml-1—acute myeloid leukemia 1.AMPK—5’AMP-activated protein kinase.ATP—adenosine triphosphate.BBB—blood-brain barrier.Bcl-2—B-cell lymphoma 2 family.<i>C. sativa—Cannabis sativa</i>.cAMP—cyclic adenosine monophosphate.CB1R—cannabinoid 1 receptor.CB2R—cannabinoid 2 receptor.CBGs—cannabigerols.CBCs—cannabichromenes.CBDs—cannabidiols.CBEs—cannabielsoins.CBLs—cannabicyclols.CBNs—cannabinols.CBNDs—cannabinodiols.CBTs—cannabitriols.CD103—cluster of differentiation 103.<i>CNR1</i>—CB1R gene.<i>CNR2</i>—CB2R gene.COX2—cytochrome c oxidase subunit 2.COX4—cytochrome c oxidase subunit 4.CYP—cytochrome P450.DGL—diacylglycerol lipase-alpha.DWI—diffusion-weighted imaging.eCBs—endocannabinoids.EGFR—epidermal growth factor receptor.EVs—extracellular vesicles.E2F1—E2F transcription factor 1.FAAH—fatty acid amide hydrolase.FAK—focal adhesion kinase.pFAK—phosphorylated FAK.FOXM1—forkhead box M1.GABA—gamma-aminobutyric acid.GBM—glioblastoma.GFAP—glial fibrillary acidic protein.GPCRs—G-protein coupled receptors.GPR55—G protein-coupled receptor 55.GRKs—G-protein receptor kinases.GSCs—glioma stem cells.GSH—glutathione.HGGs—high-grade gliomas.HSPs—heat shock proteins.IC50—half maximal inhibitory concentration.Id1—inhibitor of DNA binding 1.IDO—indoleamine 2,3-dioxygenase.IL-8—interleukin 8.LC3-I—light chain 3.LGG—low grade glioma.MAPK—p44/42 mitogen-activated protein kinase.MGL—monoacylglycerol lipase.MMP-2—matrix metalloproteinase-2.MRI—magnetic resonance imaging.mTORC1—mechanistic target of rapamycin complex 1.NAPE-PLD—N-acylphosphatidylethanolamine-hydrolysing phospholipase D.NDUFA9—NADH dehydrogenase 1 alpha subcomplex subunit 9.NDUFB8—NADH dehydrogenase 1 beta subcomplex subunit 8.NF-kB—nuclear factor kappa-light-chain-enhancer of activated B cells.NK-1—neurokinin 1.NRF2—nuclear factor erythroid 2-related factor 2.p53—cellular tumor antigen p53.p-STAT3—signal transducer and activator of transcription 3.<i>PTEN</i>—phosphatase and tensin homolog gene.Rb—retinoblastoma protein.RELA—v-rel reticuloendotheliosis viral oncogene homolog A.ROS—reactive oxygen species.RTKs—receptor tyrosine kinases.SCs—synthetic cannabinoids.Sox2—sex determining region Y box 2.Δ<sup>8</sup>-THCs—Δ<sup>8</sup>-<i>trans</i>-tetrahydrocannabinols.Δ<sup>9</sup>-THCs, THCs—Δ<sup>9</sup>-<i>trans-</i>tetrahydrocannabinols.TME—tumor microenvironment.TMZ—temozolomide.<i>TP53</i>—p53 protein gene.TRPA—transient receptor potential ankyrin.TRPM—transient receptor potential melastatin.TRPV1—transient receptor potential cation channel subfamily V member 1.TRPV2—transient receptor potential cation channel subfamily V member 2.TRPV4—transient receptor potential cation channel subfamily V member 4.VEGFR-2—vascular endothelial growth factor receptor 2.