Pelzer, Uwe
Blanc, Jean-Frédéric
Melisi, Davide
Cubillo, Antonio
Von Hoff, Daniel D
Wang-Gillam, Andrea
Chen, Li-Tzong
Siveke, Jens T
Wan, Yin
Solem, Caitlyn T
Botteman, Marc F
Yang, Yoojung
de Jong, Floris A
Hubner, Richard A
Article History
Received: 8 July 2016
Revised: 31 January 2017
Accepted: 5 February 2017
First Online: 28 March 2017
Competing interests
: UP has no disclosures. J-FB has received honoraria for lectures and consultancy and travel grants from Amgen, Bayer, Celgene, Merck, Roche and Sanofi-Aventis. J-FB has had a consultant or advisory role at Merck, Amgen, and Lilly. DM is a consultant for Lilly, and has received travel, accommodations, or expenses from Lilly and Celgene. AC has no disclosures. DDVH is employed by McKesson, and has had a consultant or advisory role at Arsia Therapeutics, Bionomics, Bristol-Myers Squibb, Cavion, Cerulean Pharma, CytRX Corporation, Dalian Wanchun Biotechnology, DNAtrix, Esperance Pharmaceuticals, Five Prime Therapeutics, Formula Pharmaceuticals, HealthCare Pharmaceuticals, Ignyta, Imaging Endpoints, Immodulon Therapeutics, Inform Genomics, Insys Therapeutics, Lilly, Medelis, Medical Prognosis Institute, Merus, miRNA Therapeutics, NuCana BioMed, Oncolytics Biotech, Pain Therapeutics, Pharmacyclics, Samumed, Senhwa Biosciences, Superlab Far East, Theravance, Tolero Pharmaceuticals, Toray Industries, Trovagene, Alethia Biotherapeutics, Alpha Cancer Technologies, Arvinas. Bellicum Pharmaceuticals, Biological Dynamics, CanBas, Horizon Discovery, Innate Pharma, Kinex, Lixte Biotechnology, MBC Pharma, Oncolyze, RenovoRx, Samsung, TD2, AADi, Aptose Biosciences, BiolineRx, CV6 Therapeutics, CytomX Therapeutics, Deciphera, EMD Serono, Evelo Therapeutics, Fujifilm, Gilead Sciences, Histogen, Horizon Pharma, Idera, Intezyne Technologies, Kalos Therapeutics, Kura, Lantern Pharma, Pain Therapeutics, Pfizer, Pharmamab, Phosplatin Therapeutics, Progen, SOTIO, Strategia Therapeutics, Sun Biopharma, Systems Imagination, Ventana Medical Systems. DDVH has received travel, accommodations, or expenses from FORMA Therapeutics and Merrimack. DDVH’s patents, royalties, and other intellectual property include: intramedullary catheter, methods of human prostate cancer, use of 5,6-dihydro-5-azacytidine in the treatment of prostate cancer, targeting site-2 protease (S2P) for the treatment of pancreatic cancer (pending), targeting ecto-5-nucleotidase (CD73) for the treatment of pancreatic cancer, targeting a protein tyrosine phosphotase-PRL-1 for the treatment of pancreatic cancer (pending), targeting a protein PRC1 for the treatment of pancreatic cancer (pending), protein kinase inhibitors (pending), methods, compounds and compositions with genotype selective anticancer activity (pending), methods and kits to predict therapeutic outcome of BTK inhibitors (pending), muscle fatigue substance cytokines and methods of inhibiting tumour growth therewith (pending), 2-arylpyridylazoles for the treatment of solid tumours such as pancreatic cancer (pending). DDVH has stock or ownership interests in cell therapeutics, McKesson, Medtronic, CerRx, EmergingMed, and SynDevRx. DDVH has received honoraria from Celgene, Cerulean Pharma, and Genentech. DDVH’s institution has received research funding from Lilly, Genentech, Celgene, Agios, Incyte, Merrimack, Plexxikon, Minneamrita Therapeutics, 3-V Biosciences, Abbvie, Aduro Biotech, ArQule, Baxalta, Biomarin, Cleave Biosciences, CytRx Corporation, Daiichi Sankyo, Deciphera, Endocyte, Exelixis, ESSA, Five Prime Therapeutics, Gilead Sciences, Merck, miRNA Therapeutics, Pfizer, Pharmacyclics, Phoenix Biotech, Proderm IQ, Sammumed, Strategia, Trovagene, and Verastem. AW-G has had a consultant or advisory role at Merrimack and Pfizer. AW-G has received travel, accommodations, or expenses from Axis Pharma. AW-G received honoraria from Pfizer and Merrimack. AW-G’s institution has received research funding from Newlink Genetics, Precision Therapeutics, AstraZeneca, Merrimack, Aduro Biotech, Prometheus, EMD Serono, Pfizer, Halozyme, OncoMed, and CTI. L-TC received honoraria from and has had a consulting or advisory role at PharmaEngine and Merrimack. JTS has had a consulting or advisory role at Merrimack, Lilly, Amcure, Baxalta (now Shire), and Celgene. JTS has received research funding from Novartis, Boehringer Ingelheim, and Celgene. YW is employed by Pharmerit. YW’s institution has received consulting or advisory role and research funding from Baxalta (now Shire) and numerous other sponsors from the pharmaceutical industry. CTS is employed by Pharmerit. CTS’s institution has received consulting or advisory role and research funding from Baxalta (now Shire) and numerous other sponsors from the pharmaceutical industry. MFB is employed by Pharmerit, and has stock or ownership interests in Pharmerit. MFB’s institution has received consulting or advisory role and research funding from Baxalta (now Shire) and numerous other sponsors from the pharmaceutical industry. YY is employed by Baxalta (now Shire) and has stock or ownership interests in Baxalta (now Shire). FAdJ is employed by Baxalta (now Shire) and has stock or ownership interests in Baxalta (now Shire). RAH has had a consulting or advisory role with BTG and Celgene.