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Article History

Received: 8 August 2014

Revised: 18 December 2014

Accepted: 19 December 2014

First Online: 21 January 2015

Competing interests

: This study was funded exclusively by in-house institutional funding from the Technische Universität München and the Helmholtz Zentrum München, Munich, Germany. There was no industry sponsorship. The KORA-Age project was funded by the German Ministry for Education and Research (BMBF) FKZ 01ET0713 and 01ET1003. BM has received grants from TEVA-Pharma, Desitin, Boehringer-Ingelheim and GE Healthcare and honoraria for consultancy from Bayer Schering Pharma AG and for presentations from GlaxoSmithKline and Orion Pharma as well as travel and meeting expenses from Boehringer-Ingelheim and Novartis. DH is currently employed by the Medical University of Vienna, Austria, and received research support through the National Institute of Neurological Disorders and Stroke Intramural Research Program and the Austrian Science Fund (FWF). He serves as member of the Medical Advisory Board of the International Essential Tremor Foundation and received honoraria and conference support from Ipsen and UCB. Walter Pirker received speaker honoraria from AOP Orphan Pharma, Medtronic Inc., Novartis, Boehringer-Ingelheim, Abbott Pharm and UCB as well as travel compensation from Ipsen Pharma, Boehringer-Ingelheim and Medtronic, Inc. BB and MJM receive research support from the Hungarian National Innovation Office (TÁMOP-4-2-1/B-03/1/KMR-2010-001). The functional analyses were supported by the European Research Council under the European Union's Seventh Framework Program (FP7/20072013)/ ERC Grant Agreement No. 321366-Amyloid (advanced grant to CH) and the general legacy of Mrs Ammer (to the Ludwig-Maximilians University/the chair of C.H.). PP is funded by a grant of the Spanish Ministry of Science and Innovation SAF-2010-22329-C02-01: 2011–2013. XE is funded by the Spanish Plan Nacional SAF-2008-00357 (NOVADIS); the Generalitat de Catalunya AGAUR 2009 SGR-1502; and the European Commission 7th Framework Program, Project No 261123 (GEUVADIS) and Project No 262055 (ESGI). JW serves on a scientific advisory board for UCB and has received speaker honoraria from UCB and Vifor Pharma. The remaining authors declare no conflict of interest.