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The complete structure of the large subunit of the mammalian mitochondrial ribosome

Crossref DOI link: https://doi.org/10.1038/nature13895

Published Online: 2014-10-01

Published Print: 2014-11

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Greber, Basil J.

Boehringer, Daniel

Leibundgut, Marc

Bieri, Philipp

Leitner, Alexander

Schmitz, Nikolaus

Aebersold, Ruedi

Ban, Nenad
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Article History

Received: 23 July 2014

Accepted: 26 September 2014

First Online: 1 October 2014

Competing interests

: CFI–ETH Zürich has filed a patent application to use the coordinates of the 39S mitoribosomal subunit for development of compounds that can (1) specifically bind to the mitochondrial ribosome and interfere with mitochondrial translation or (2) specifically inhibit translation of pathogenic organisms without interfering with mitochondrial translation.