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Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

Crossref DOI link: https://doi.org/10.1038/nbt.4005

Published Online: 2017-11-13

Published Print: 2017-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yin, Hao

Song, Chun-Qing

Suresh, Sneha

Wu, Qiongqiong

Walsh, Stephen

Rhym, Luke Hyunsik

Mintzer, Esther

Bolukbasi, Mehmet Fatih https://orcid.org/0000-0002-5612-3881
Zhu, Lihua Julie https://orcid.org/0000-0001-7416-0590
Kauffman, Kevin

Mou, Haiwei

Oberholzer, Alicia

Ding, Junmei

Kwan, Suet-Yan

Bogorad, Roman L

Zatsepin, Timofei https://orcid.org/0000-0003-0030-9174
Koteliansky, Victor

Wolfe, Scot A

Xue, Wen https://orcid.org/0000-0002-9797-8042
Langer, Robert

Anderson, Daniel G
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Article History

Received: 29 November 2016

Accepted: 9 October 2017

First Online: 13 November 2017

Competing interests

: H.Y., D.G.A. and R.L. have applied for patents related to this study. D.G.A. is a scientific co-founder of CRISPR Therapeutics.