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Catalytic in vivo protein knockdown by small-molecule PROTACs

Crossref DOI link: https://doi.org/10.1038/nchembio.1858

Published Online: 2015-06-10

Published Print: 2015-08

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Bondeson, Daniel P

Mares, Alina

Smith, Ian E D

Ko, Eunhwa

Campos, Sebastien

Miah, Afjal H

Mulholland, Katie E

Routly, Natasha

Buckley, Dennis L

Gustafson, Jeffrey L

Zinn, Nico

Grandi, Paola

Shimamura, Satoko

Bergamini, Giovanna

Faelth-Savitski, Maria

Bantscheff, Marcus

Cox, Carly

Gordon, Deborah A

Willard, Ryan R

Flanagan, John J

Casillas, Linda N

Votta, Bartholomew J

den Besten, Willem

Famm, Kristoffer

Kruidenier, Laurens

Carter, Paul S

Harling, John D

Churcher, Ian

Crews, Craig M http://orcid.org/0000-0002-8456-2005
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Article History

Received: 8 May 2015

Accepted: 3 June 2015

First Online: 10 June 2015

Competing interests

: A.M., I.E.D.S., S.C., A.M., N.Z., P.G., S.S., G.B., M.F.-S., M.B., L.N.C., B.J.V., K.F., L.K., P.S.C., J.D.H. and I.C. are employees of GlaxoSmithKline. D.A.G., R.R.W. and J.J.F. are employees of Arvinas, LLC. C.M.C. is a shareholder/consultant for Arvinas, LLC and consults for Canaan Partners.