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Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

Crossref DOI link: https://doi.org/10.1038/nchembio.2370

Published Online: 2017-05-01

Published Print: 2017-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Lauinger, Linda

Li, Jing

Shostak, Anton

Cemel, Ibrahim Avi

Ha, Nati

Zhang, Yaru

Merkl, Philipp E

Obermeyer, Simon

Stankovic-Valentin, Nicolas

Schafmeier, Tobias

Wever, Walter J

Bowers, Albert A

Carter, Kyle P

Palmer, Amy E

Tschochner, Herbert

Melchior, Frauke

Deshaies, Raymond J

Brunner, Michael

Diernfellner, Axel
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Article History

Received: 30 November 2016

Accepted: 22 March 2017

First Online: 1 May 2017

Competing interests

: R.J.D. is a founder, shareholder, member of the scientific advisory board and consultant of Cleave Biosciences, which is developing drugs that target protein homeostasis in cancer.