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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Crossref DOI link: https://doi.org/10.1038/nm.4010

Published Online: 2015-12-14

Published Print: 2016-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Chang, Jianhui

Wang, Yingying

Shao, Lijian

Laberge, Remi-Martin

Demaria, Marco

Campisi, Judith

Janakiraman, Krishnamurthy

Sharpless, Norman E

Ding, Sheng

Feng, Wei

Luo, Yi

Wang, Xiaoyan

Aykin-Burns, Nukhet

Krager, Kimberly

Ponnappan, Usha

Hauer-Jensen, Martin

Meng, Aimin

Zhou, Daohong
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Article History

Received: 27 August 2015

Accepted: 16 November 2015

First Online: 14 December 2015

Competing interests

: J. Chang, Y.W., L.S., W.F., Y.L., and D.Z. are inventors of a pending patent application for use of Bcl-2 and/or Bcl-xL inhibitors as anti-aging agents. J. Campisi and D.Z. are co-founders and advisors of Cenexys/Unity that develops senolytic drugs.