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Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design

Published Online: 2015-09-21

Published Print: 2015-10

Authors

Kotecha, Abhay

Seago, Julian

Scott, Katherine

Burman, Alison

Loureiro, Silvia

Ren, Jingshan

Porta, Claudine

Ginn, Helen M

Jackson, Terry

Perez-Martin, Eva

Siebert, C Alistair

Paul, Guntram

Huiskonen, Juha T

Jones, Ian M

Esnouf, Robert M

Fry, Elizabeth E

Maree, Francois F

Charleston, Bryan

Stuart, David I
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Text and Data Mining valid from 2015-09-21

Version of Record valid from 2015-09-21
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Article History

Received: 6 May 2015

Accepted: 26 August 2015

First Online: 21 September 2015

Competing interests

: A number of the stabilizing mutations are patented (patent no. WO 2014154655 A1, patent holders: R.M.E., E.E.F., A.K. and D.I.S.), and work on a VLP-based stabilized vaccine antigen is ongoing at Intervet (MSD Animal Health), in collaboration with the authors (except that F.F.M. and K.S. are not part of this ongoing work). This work was not funded by MSD Animal Health but by a Wellcome Trust Translation Award.

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