Liang, Qiaowei https://orcid.org/0000-0002-5207-9588
Uchiyama, Yuri https://orcid.org/0000-0002-4540-5277
Seyama, Rie
Kuki, Ichiro
Haginoya, Kazuhiro https://orcid.org/0000-0003-0150-5716
Shinozaki, Toshiyuki
Kato, Mitsuhiro https://orcid.org/0000-0003-1485-8553
Sakamoto, Masamune
Tsuchida, Naomi https://orcid.org/0000-0001-7203-884X
Koshimizu, Eriko https://orcid.org/0000-0001-9947-3315
Fujita, Atsushi https://orcid.org/0000-0003-1572-1014
Miyatake, Satoko https://orcid.org/0000-0001-7587-5168
Mizuguchi, Takeshi https://orcid.org/0000-0003-4998-1244
Matsumoto, Naomichi https://orcid.org/0000-0001-9846-6500
Funding for this research was provided by:
Japan Agency for Medical Research and Development (JP25ek0109674)
Japan Agency for Medical Research and Development (JP25ek0109760)
Japan Agency for Medical Research and Development (JP25ek0109617)
Japan Agency for Medical Research and Development (JP25ek0109648)
Japan Agency for Medical Research and Development (JP25ek0109677)
MEXT | Japan Society for the Promotion of Science (JP24K02230)
MEXT | Japan Society for the Promotion of Science (JP23K07229)
MEXT | Japan Society for the Promotion of Science (JP24K18862)
MEXT | Japan Society for the Promotion of Science (JP23K15353)
MEXT | Japan Society for the Promotion of Science (JP21K07869)
MEXT | Japan Society for the Promotion of Science (JP23K27520)
MEXT | Japan Society for the Promotion of Science (JP23K27568)
MEXT | Japan Society for the Promotion of Science (JP23K18278)
Takeda Science Foundation
Article History
Received: 6 September 2025
Revised: 5 October 2025
Accepted: 8 October 2025
First Online: 6 November 2025
Competing interests
: The authors declare no competing interests.