Yuan, Jun-Hui https://orcid.org/0000-0002-3808-7813
Higuchi, Yujiro
Ando, Masahiro https://orcid.org/0000-0002-6187-9042
Hashiguchi, Akihiro
Okamoto, Yuji
Hiramatsu, Yu
Yoshimura, Akiko
Kodama, Kento
Sakiyama, Yusuke
Mitsui, Jun https://orcid.org/0000-0001-7425-4765
Tsuji, Shoji https://orcid.org/0000-0001-5602-5686
Takashima, Hiroshi https://orcid.org/0000-0003-0989-6141
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (JP22K07495)
MEXT | Japan Society for the Promotion of Science (JP22K07495)
MEXT | Japan Society for the Promotion of Science (JP20K16604, JP22K07519)
MEXT | Japan Society for the Promotion of Science (JP21K15702, JP23K06966)
MEXT | Japan Society for the Promotion of Science (JP24K18708)
MEXT | Japan Society for the Promotion of Science (JP22K15713)
MEXT | Japan Society for the Promotion of Science (JP18H02742, JP21H02842)
Ministry of Health, Labour and Welfare (2016100002B)
Japan Agency for Medical Research and Development (201442014A, 201442071A)
Article History
Received: 8 September 2025
Revised: 2 October 2025
Accepted: 14 November 2025
First Online: 8 December 2025
Competing interests
: The authors declare no competing interests.