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ELK1 inhibition alleviates amyloid pathology and memory decline by promoting the SYVN1-mediated ubiquitination and degradation of PS1 in Alzheimer’s disease

Crossref DOI link: https://doi.org/10.1038/s12276-025-01455-8

Published Online: 2025-05-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yi, Lilin

Li, Junjie

He, Yan

Wang, Jiaojiao

Wang, Maoju

Guo, Song

Luo, Man

Wu, Bin

Xu, Mingliang

Tian, Qiuyun

Fan, Yepeng

Chen, Mulan

Xu, Boqing

Xia, Lei

Song, Weihong https://orcid.org/0000-0001-9928-889X
He, Guiqiong

Du, Yehong

Dong, Zhifang https://orcid.org/0000-0002-3411-7923
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (32371030, 82371194, 82371203, 82071395)

Natural Science Foundation of Chongqing (CSTB2022NSCQ-LZX0010, CSTB2023NSCQ-MSX0161, CSTB2024NSCQ-LZX0008))
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Text and Data Mining valid from 2025-05-01

Version of Record valid from 2025-05-01
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Article History

Received: 2 December 2024

Revised: 19 February 2025

Accepted: 11 March 2025

First Online: 1 May 2025

Competing interests

: The authors declare no competing interests.

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