Belle, Steven H.
Gallagher, Dympna
Roberts, Susan B. https://orcid.org/0000-0003-1320-8460
Laughlin, Maren R.
Das, Sai Krupa https://orcid.org/0000-0003-0788-0461
Whyte, Kathryn J.
King, Wendy C. https://orcid.org/0000-0002-0740-0029
Saks, Rachel
Yanovski, Susan Z.
Fielding, Roger A.
Mayer, Laurel E. S.
Hayes, Matthew R. https://orcid.org/0000-0001-9782-6551
Rosenbaum, Michael https://orcid.org/0000-0003-2835-9202
Allison, Kelly C. https://orcid.org/0000-0002-9807-0220
Lowe, Michael https://orcid.org/0000-0002-6301-9214
Leibel, Rudolph https://orcid.org/0000-0002-6062-7222
Jakicic, John M. https://orcid.org/0000-0001-6800-9368
,
,
Mayer, Laurel
Ashby-Thompson, Maxine
Benasi, Giada
Foerde, Karin
Goldsmith, Rochelle
Hirano, Michio
LeDuc, Charles
Roberto, Christina
Seid, Heather
St-Onge, Marie-Pierre
Whyte, Kathryn
Zhang, Yiying
Aparicio, Alexis O.
Dratsky, Daaimah
Goodpaster, Bret
Gu, Jingrui
Horowitz, Michelle
Lin, Susan Xiaoqin
McMath, Arden
Mikula, Cynthia
Nunez, Joel Matos
Picard, Martin
Schebendach, Janet
Sun, Yifei
Wong, Agnes
Yu, Wen Wen
,
Burger, Kyle
Fielding, Roger
Rickels, Michael
Roalf, David
Speakman, John
Wu, Gary
Zamani, Payman
Chau, Lillian
Czernuszenko, Adam
Demastus, Cassandra
Fernando, Melissa
Ghias, Kubarah
Gomez, Alexis
Grosso, Gabrielle
Hambly, Catherine
Herman, Lindsay
Holmes, Nathaniel
Howland, Andrew
Mastracchio, Christina
Meierovich, Sophie
Sayana, Varsha
Scharf, Mars
Wellman, Nicholas
Williams, Edward
Zhou, Anna
Zhu, Olive
,
Benos, Panayiotis V.
Wahed, Abdus S.
Erickson, Kirk I.
Hallam, David
Haller, Tamara
Kelley, Stephanie S.
Kline, Christopher E.
Leonard, Kelsey R.
Pelesko, Andrew J.
Zourelias, Matthew
,
Kowtha, Bramaramba
Laughlin, Maren R.
Yanovski, Susan
Young-Hyman, Deborah
Article History
Received: 3 February 2025
Revised: 15 September 2025
Accepted: 9 October 2025
First Online: 12 December 2025
Competing interests
: SBR is a Board member of Danone and a founder of a weight loss platform ( ) that has no role in this study. KJW is partially funded by Eli Lilly & Company. Dr. Yanovski reports that her spouse has received research project support to his Institution from Soleno Therapeutics and Rhythm Pharmaceuticals and receives medication for studies from Hikma Pharmaceuticals and Versanis Bio. Dr. Fielding reports personal fees and other from Axcella Health, other from Juvicell, other from Inside Tracker, grants and personal fees from Biophytis, personal fees from Amazentis, Nestle, Pfizer, Rejuvenate Biomed, Embion and Hevolution Foundation, outside the submitted work. Dr. Hayes receives research funding from Boehringer Ingelheim, Eli Lilly & Co., Pfizer, Novo Nordisk, and Gila Therapeutics. Dr. Rosenbaum has funding from Eli Lilly & Co. and is a paid consultant for Scholar Rock. Dr. Allison receives research funding from Novo Nordisk, which was not used in support of this work. Dr. Lowe receives licensing fees for the Power of Food Scale, but not from the POWERS consortium. Dr. Leibel is a consultant to Coronation Bio, MBX Biosciences, and Eli Lilly & Co. Dr. Jakicic is on the Scientific Advisory Board for Wondr Health, Inc. and his institution received research funding from Epitomee Medical, Inc. The remaining authors declare no competing financial interests.
: Methods and procedures for the study will be performed in accordance with guidelines and regulations as required by the single Institutional Review Board (IRB) at the University of Pittsburgh (STUDY21120046), which approved the protocol and informed consent forms, or a local site IRB. All participants provided, or will provide, informed consent prior to enrolling in the study. There are no identifiable images from human research participants in this manuscript.