Article History
Received: 23 May 2025
Revised: 25 October 2025
Accepted: 17 November 2025
First Online: 2 December 2025
Competing interests
: The authors declare no competing interests.
: The UK biobank has the ethical approval from the North West Multi-centre Research Ethics Committee (approval number: 16/NW/0274). The present analysis plan was approved by both the UK Biobank data committee (Application ID: 177053). All participants signed informed consent. All methods were performed in accordance with the relevant guidelines and regulations.
: All authors read and approved the final manuscript.