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Authors
Heinonen, S. https://orcid.org/0000-0002-6342-0577
Karppinen, J. E. https://orcid.org/0000-0002-9886-9067
Saarinen, T. https://orcid.org/0000-0002-7508-4849
Groop, P-H
Juuti, A.
Holst, J. J. https://orcid.org/0000-0001-6853-3805
Pietiläinen, K. H. https://orcid.org/0000-0002-8522-1288
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Article History
Received: 3 July 2025
Revised: 4 November 2025
Accepted: 5 December 2025
First Online: 6 January 2026
Competing interests
: The authors declare no competing interests.
: The study was approved centrally by the Helsinki University Hospital Ethics Committee DNro 1/13/03/02/2016 (RYSA), registered at ClinicalTrials.gov ID NCT02882685, and reviewed by the Helsinki University Hospital Research Review Board. Informed consent was obtained from all study participants.
