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The effect of obesity and aging on NAD+/Sirtuin metabolism transcription and DNA methylation in subcutaneous adipose tissue of monozygotic twin pairs discordant for BMI

Crossref DOI link: https://doi.org/10.1038/s41366-025-02007-w

Published Online: 2026-01-05

Published Print: 2026-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Lapatto, Helena A. K. https://orcid.org/0000-0002-6655-4415
van der Kolk, Birgitta W. https://orcid.org/0000-0001-8608-541X
Muniandy, Maheswary https://orcid.org/0000-0001-7624-7948
Heinonen, Sini https://orcid.org/0000-0002-6342-0577
Heikkinen, Aino https://orcid.org/0000-0001-5770-6475
Alvarez, Marcus

Lee, Seung Hyuk T. https://orcid.org/0000-0002-0943-6076
Jokinen, Riikka

Lundbom, Jesper

Kuula, Juho

Hakkarainen, Antti

Groop, Per-Henrik

Kaprio, Jaakko https://orcid.org/0000-0002-3716-2455
Tukiainen, Taru

Ollikainen, Miina https://orcid.org/0000-0003-3661-7400
Pajukanta, Päivi

Pirinen, Eija

Pietiläinen, Kirsi H. https://orcid.org/0000-0002-8522-1288
License Information

Text and Data Mining valid from 2026-01-05

Version of Record valid from 2026-01-05
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Article History

Received: 21 March 2025

Revised: 1 December 2025

Accepted: 11 December 2025

First Online: 5 January 2026

Competing interests

: The authors declare no competing interests.

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