Pluym, Nikola
Burkhardt, Therese
Weber, Till
Scherer, Gerhard
Scherer, Max
Kolossa-Gehring, Marike
Article History
Received: 18 July 2024
Revised: 28 November 2025
Accepted: 15 January 2026
First Online: 28 January 2026
Competing interests
: The authors declare no competing interests.
: The study protocol for collection of the ESB samples has been approved by the ethics committee of the Medical Association Westfalen-Lippe, the Medical Faculty of the University of Münster and (since 2012) by the ethical committee of the Medical Association of the Saarland (Reg. No.: HA02/12). The study was conducted in compliance with both European and national legal and ethical requirements in accordance with the Declaration of Helsinki in its version of Fortaleza, 2013. All participants provided written, informed consent prior to participating.