Ernst, Michael E. https://orcid.org/0000-0003-0267-4888
Sheets, Kerry M.
Webb, Katherine L. https://orcid.org/0000-0002-9380-6075
Fravel, Michelle A.
Woods, Robyn L.
Beilin, Lawrence https://orcid.org/0000-0003-4853-7360
Orchard, Suzanne G.
Shah, Raj C. https://orcid.org/0000-0001-9706-9730
Polkinghorne, Kevan R.
Reid, Christopher M.
Wolfe, Rory
Murray, Anne
Lacaze, Paul
Ryan, Joanne
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U01AG029824, U19AG062682)
Department of Health | National Health and Medical Research Council (334037, 1127060)
Article History
Received: 9 June 2025
Revised: 30 September 2025
Accepted: 14 October 2025
First Online: 18 October 2025
Ethical approval
: The ASPREE trial adhered to the principles of the Declaration of Helsinki and international standards pertaining to protection of human subjects, and was approved by local institutional review boards at each site.
: All authors declare no competing interests. A portion of this work was presented as a flatboard poster abstract at the 2024 AHA Hypertension Sessions, September 5–7, 2024, Chicago, Ill.