Brumback, Lyndia C. https://orcid.org/0000-0002-9606-1558
Jacobs, David R. Jr.
Duprez, Daniel A. https://orcid.org/0000-0002-0993-6839
Allison, Matthew A.
Hughes, Timothy M.
Heckbert, Susan R.
Rapp, Stephen R.
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute
Article History
Received: 12 July 2025
Revised: 4 March 2026
Accepted: 16 March 2026
First Online: 7 April 2026
Competing interests
: The authors declare no competing interests.
: Written informed consent was obtained from all MESA participants. The study was approved under single Institutional Review Board (IRB) review by the IRB at the University of Washington. The University of Washington is certified by the U.S. Office of Human Research Protections: IRB number STUDY00014523 under Federal-wide Assurance-FWA0000687. The Standard Operating Procedures (SOPs) of the IRB conduct reviews and provide assurance that research is conducted in accordance with the legal and regulatory requirements in the U.S.A. and specifically in accordance with the Common Rule (Subpart A of the HHS regulations for the protection of human subjects at 45 CFR 46), other applicable federal regulations and state laws, and with the International Council for Harmonisation (ICH) Guideline for Good Clinical Practice (E6) to the extent that it is consistent with applicable US federal law/regulations.