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Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs

Crossref DOI link: https://doi.org/10.1038/s41375-024-02284-w

Published Online: 2024-06-14

Published Print: 2024-08

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hoferkova, Eva https://orcid.org/0000-0002-7185-6119
Seda, Vaclav https://orcid.org/0000-0003-0234-6470
Kadakova, Sona https://orcid.org/0000-0002-7644-6207
Verner, Jan

Loja, Tomas

Matulova, Kvetoslava

Skuhrova Francova, Hana

Ondrouskova, Eva https://orcid.org/0000-0003-0830-0692
Filip, Daniel

Blavet, Nicolas https://orcid.org/0000-0003-2199-9119
Boudny, Miroslav

Mladonicka Pavlasova, Gabriela

Vecera, Josef

Ondrisova, Laura

Pavelkova, Petra

Hlavac, Krystof

Kostalova, Lenka

Michaelou, Androniki

Pospisilova, Sarka https://orcid.org/0000-0001-7136-2680
Dorazilova, Jana

Chochola, Vaclav https://orcid.org/0000-0003-3674-5701
Jaros, Josef

Doubek, Michael https://orcid.org/0000-0002-1269-6282
Jarosova, Marie

Hampl, Ales

Vojtova, Lucy https://orcid.org/0000-0001-5281-7045
Kren, Leos

Mayer, Jiri https://orcid.org/0000-0003-0567-9887
Mraz, Marek https://orcid.org/0000-0001-6975-8838
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Text and Data Mining valid from 2024-06-14

Version of Record valid from 2024-06-14
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Article History

Received: 11 March 2024

Revised: 3 May 2024

Accepted: 9 May 2024

First Online: 14 June 2024

Competing interests

: The authors declare no competing interests.

: CLL samples were collected in accordance with the Declaration of Helsinki with written informed consent obtained from all patients and the Institutional Ethical Review Board approved the study (Masaryk University, No. EKV-2022-068).

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