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Authors
Halilovic, Melisa
Abdelsalam, Mohamed
Zabkiewicz, Joanna
Lazenby, Michelle
Alvares, Caroline https://orcid.org/0000-0003-4391-9802
Schmidt, Matthias
Brenner, Walburgis https://orcid.org/0000-0002-1511-6212
Najafi, Sara
Oehme, Ina
Hieber, Christoph
Zeyn, Yanira https://orcid.org/0000-0002-2501-8149
Bros, Matthias
Sippl, Wolfgang https://orcid.org/0000-0002-5985-9261
Krämer, Oliver H. https://orcid.org/0000-0003-3973-045X
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Funding
Funding for this research was provided by:
Deutsche Forschungsgemeinschaft (KR2291)
Deutsche Forschungsgemeinschaft (SI 868/26-1, DFG-project number 49527183)
Brigitte und Dr. Konstanze Wegener-Stiftung Walter Schulz Stiftung Deutsche José Carreras Leukämie-Stiftung
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Article History
Received: 3 April 2024
Revised: 28 August 2024
Accepted: 2 September 2024
First Online: 17 September 2024
Competing interests
: OHK declares the patents WO2019/034538, WO2016020369A1, and WO/2004/027418, and paid advisory work for the BASF Ludwigshafen, Germany. WO2019/034538 (Synthesis, Pharmacology and use of New and Selective FMS-like tyrosine kinase 3 (FLT3) FLT3 Inhibitors) covers substance classes that are discussed in this work. The substances that are covered in these patents are not the same that are shown in the submitted manuscript. The BASF has not influenced our study, and its products are not discussed in the manuscript. Thus, there are no direct competing interests. All other authors declare that they have no conflict of interest.
: Peripheral blood and bone marrow samples were obtained from AML patients with written informed consent in accordance with the Declaration of Helsinki under ethical approval REC: 17/LO/1566. Institutional Review Board Statement Zebrafish husbandry (permit number 35-9185.64/BH Hassel) and experiments (permit number 35-9185.81/G-126/15) were performed according to local animal welfare standards (Tierschutzgesetz §11, Abs. 1, No. 1) and in accordance with European Union animal welfare guidelines (EU Directive 2010/63/EU). All applicable national and institutional guidelines for the care and use of zebrafish were followed. C57BL/6 mice were bred and maintained in the Central Animal Facility of the Johannes Gutenberg-University Mainz under specific pathogen-free conditions on a standard diet according to the guidelines of the regional animal care committee. The “Principles of Laboratory Animal Care” (NIH publication no. 85-23, revised 1985) were followed. Mice at 12 weeks of age were sacrificed for organ retrieval according to § 4(3) TierSchG.
