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Authors
Borges, Gabriel Alvares
Diaz-delCastillo, Marta https://orcid.org/0000-0001-7719-6839
Guilatco, Angelo J.
El-Masri, Bilal Mohamad
Mustapha, Fatima A.
Gundesen, Michael T.
Hinge, Maja
Lund, Thomas
Abdallah, Nadine https://orcid.org/0000-0001-9195-1589
Baughn, Linda B. https://orcid.org/0000-0001-5229-4897
Xu, Ming https://orcid.org/0000-0002-4477-939X
Gingery, Anne https://orcid.org/0000-0002-1690-7382
Tchkonia, Tamar
Kirkland, James L. https://orcid.org/0000-0003-1676-4905
Kourelis, Taxiarchis https://orcid.org/0000-0001-8573-9434
Drake, Matthew T.
Andersen, Thomas Levin
Weivoda, Megan M. https://orcid.org/0000-0003-0240-0123
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Funding
Funding for this research was provided by:
U.S. Department of Health & Human Services | National Institutes of Health (AG075227)
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Article History
Received: 3 October 2024
Revised: 18 February 2025
Accepted: 14 March 2025
First Online: 31 March 2025
Competing interests
: TT and JLK have a financial interest related to this research, including patents and pending patents covering senolytic drugs and their uses held by Mayo Clinic. This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and was conducted in compliance with Mayo Clinic conflict of interest policies.
: All methods described in this manuscript were performed in accordance with the relevant guidelines and regulations. The human study protocols reported in this manuscript were conducted in accordance with the Declaration of Helsinki. Patients who donated bone marrow aspiration samples and peripheral plasma provided written informed consent in accordance with the biobanking study protocol, which was approved by the Mayo Clinic Institutional Review Board under the number 521-93. Analyses of these samples was approved by the Mayo Clinic Institutional Review Board under the number 20-002263. Trephine iliac crest bone biopsies from MGUS, SMM, and NDMM patients were obtained from Danish pathological biobanks under approval from the Danish National Committee on Biomedical Research Ethics (S-20190110) and in compliance with the Declaration of Helsinki. All patients provided written informed consent. Bone biopsies from healthy individuals were included from a previous study approved by the Danish National Committee on Biomedical Research Ethics under protocol number 1-10-72-223-20, with informed consent obtained from all participants.
