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Authors
Mieland, Andreas O. https://orcid.org/0000-0002-8672-0708
Petrosino, Giuseppe https://orcid.org/0000-0002-2835-4308
Dejung, Mario
Chen, Jia-Xuan
Fulzele, Amitkumar
Mahmoudi, Fereshteh
Tu, Jia-Wey
Mustafa, Al-Hassan M. https://orcid.org/0000-0001-8850-6409
Zeyn, Yanira https://orcid.org/0000-0002-2501-8149
Hieber, Christoph https://orcid.org/0009-0002-3343-4203
Bros, Matthias https://orcid.org/0000-0002-4662-0542
Schnöder, Tina M. https://orcid.org/0000-0002-6351-4119
Heidel, Florian H. https://orcid.org/0000-0003-2438-1955
Najafi, Sara
Oehme, Ina https://orcid.org/0000-0002-0827-2356
Hofmann, Ilse https://orcid.org/0000-0002-3586-5050
Schutkowski, Mike
Hilscher, Sebastian
Kosan, Christian https://orcid.org/0000-0002-8387-3653
Butter, Falk https://orcid.org/0000-0002-7197-7279
Bhatia, Sanil https://orcid.org/0000-0001-6494-7744
Sippl, Wolfgang https://orcid.org/0000-0002-5985-9261
Krämer, Oliver H. https://orcid.org/0000-0003-3973-045X
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Article History
Received: 29 November 2024
Revised: 28 March 2025
Accepted: 7 April 2025
First Online: 29 April 2025
Competing interests
: O.H.K. declares the patents WO2019/034538, WO2016020369A1, and WO/2004/027418, and advisory work for the BASF Ludwigshafen, Germany. None of these patents cover substance classes that are discussed in this work. The BASF has not promoted, sponsored, or supported this study in any way and its products are not discussed in this publication. I.O. receives research grants from PreComb, BVD, and Day One Therapeutics.
: All methods were performed in accordance with the relevant guidelines and regulations. Mice experiments were performed in compliance with the regulatory guidelines of LANUV (Akt. 81-02.04.2017.A441) and were approved by the animal research institute (ZETT) at Heinrich Heine University Düsseldorf. Patient samples were collected with informed consent, in accordance with the Declaration of Helsinki, and the experiments were approved by the ethics committee of the medical faculty at Heinrich Heine University (Study Nr.: 2019-566). PBMCs were isolated from blood samples that were obtained from healthy anonymous donors at the Transfusion Centre of the University Medical Centre of the Johannes Gutenberg University Mainz after informed consent. Human HSPCs derived from healthy donors were obtained after informed consent and according to the Helsinki declaration. Scientific protocol, patient information, and patient approval forms were approved by the respective local ethics committees (Ethics Committee, University Medicine Greifswald BB_199-20; Hannover Medical School 11501_BO_K_2024). Institutional Review Board Statement Zebrafish husbandry (permit number 35-9185.64/BH Hassel) and experiments (permit number 35-9185.81/G-234/20) were performed according to local animal welfare standards (Tierschutzgesetz §11, Abs. 1, No. 1) and in accordance with European Union animal welfare guidelines (EU Directive 2010/63/EU). All applicable national and institutional guidelines for the care and use of zebrafish were followed.
