Suzuki, Kako https://orcid.org/0009-0007-2781-3457
Kusayanagi, Seina
Kuze, Yuta
Hata, Masato
Kozuma, Shiho
Jimbo, Koji https://orcid.org/0000-0002-2031-7385
Nannya, Yasuhito https://orcid.org/0000-0002-6526-0992
Suzuki, Yutaka
Uchimaru, Kaoru
Yamagishi, Makoto https://orcid.org/0000-0002-8142-4686
Funding for this research was provided by:
Japan Agency for Medical Research and Development (JP24ama221534)
Japan Agency for Medical Research and Development (JP23ck0106860)
Japan Agency for Medical Research and Development (JP23fk0108672)
MEXT | Japan Society for the Promotion of Science (JP24K02317)
MEXT | Japan Society for the Promotion of Science (JP22K08386)
MEXT | Japan Society for the Promotion of Science (JP22H02987)
MEXT | Japan Society for the Promotion of Science (JP22H04923)
MEXT | Japan Society for the Promotion of Science (JP24KJ0953)
Article History
Received: 30 January 2025
Revised: 7 July 2025
Accepted: 23 July 2025
First Online: 4 August 2025
Competing interests
: S.Kozuma and MH are employees of Daiichi Sankyo Co., Ltd. Daiichi Sankyo holds patents on DS-1055a. All other authors have no competing interests to declare.
: All methods described in this manuscript were performed in accordance with the relevant guidelines and regulations. The study has been approved by the Institutional Review Board of the University of Tokyo (No. 23-482). Written informed consents were obtained from all patients. This study does not include any identifiable images from human participants.