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Authors
Ho, Tzu-Chieh https://orcid.org/0000-0002-2913-9319
LaMere, Mark W.
Kawano, Hiroki
Byun, Daniel K.
LaMere, Elizabeth A.
Chiu, Yu-Chiao https://orcid.org/0000-0003-1647-8634
Chen, Chunmo
Wang, Li-Ju
Wang, Jian
Ramdas, Baskar https://orcid.org/0009-0006-2206-5720
Dokholyan, Nikolay V. https://orcid.org/0000-0002-8225-4025
Calvi, Laura M. https://orcid.org/0000-0001-6969-239X
Liesveld, Jane L. https://orcid.org/0000-0002-3386-8469
Jordan, Craig T. https://orcid.org/0000-0003-0869-3465
Singh, Rakesh K. https://orcid.org/0000-0002-1124-9202
Kapur, Reuben https://orcid.org/0009-0009-4349-1579
Becker, Michael W. https://orcid.org/0000-0001-9890-8815
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Funding
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R21CA149848)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA166280)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (P30CA044579)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA166280)
Leukemia and Lymphoma Society (7020-19)
Leukemia and Lymphoma Society (7020-19)
J. P. Wilmot Cancer Center Pilot Award, University of Rochester Technologies Development Fund, University of Rochester CTSI, Empire Discovery Institute
Indiana University Simon Comprehensive Cancer Center (IUSCCC) Early Career Investigator Award and the Wells Center Translational/Emerging Therapies Award.
Leukemia Research Foundation
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R35GM134864)
U.S. Department of Health & Human Services | NIH | National Center for Complementary and Integrative Health (R01AT012053)
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Article History
Received: 13 April 2025
Revised: 18 September 2025
Accepted: 19 November 2025
First Online: 19 December 2025
Competing interests
: MWB, RKS, and LMC hold the patent for UR241-2 (CA3186896A1, ZL202180054152.8). The remaining authors have declared that no conflict of interest exists.
: All methods were performed in accordance with the relevant guidelines and regulations. All samples from AML patients or healthy donors were obtained with informed consent and in accordance with protocols approved by the Institutional Review Board (IRB) at the URMC (URCC: LEU 07047) and Roswell Park Comprehensive Cancer Center. Additionally, animal experiments conducted in this study were approved by the Institutional Animal Care and Use Committees (IACUCs) at the URMC (UCAR-2005-256E) and IUSM (#24038).
