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Authors
Struckman, Nadine E.
Koutsoumpli, Georgia
de Jong, Rob C. M.
van der Lee, Dyantha I.
Remst, Dennis F. G.
Smith, Sophie-Anne I.
Honders, M. Willy
Hagedoorn, Renate S.
de Ru, Arnoud H.
Matsuda, Masashi
Ishikawa, Fumihiko
Tak, Tamar https://orcid.org/0000-0002-5959-7927
Valk, Peter J. M. https://orcid.org/0000-0002-8857-9461
Heemskerk, Mirjam H. M. https://orcid.org/0000-0001-6320-9133
van Veelen, Peter A. https://orcid.org/0000-0002-7898-9408
Falkenburg, J. H. Frederik
Griffioen, Marieke https://orcid.org/0000-0002-3001-4441
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Article History
Received: 14 June 2025
Revised: 9 October 2025
Accepted: 19 November 2025
First Online: 12 December 2025
Competing interests
: The authors declare no competing interests.
: All methods were performed in accordance with the relevant guidelines and regulations, including the Declaration of Helsinki. Approval to use RUNX1 -mutated AML patient samples for this research was obtained from the Leiden University Medical Center (LUMC) Institutional Review Board (approval number B16.039). Peripheral blood mononuclear cells (PBMC) from healthy individuals were obtained from fresh buffy coats (Sanquin; framework agreement NVT20221012). Written informed consent to participate was obtained from all participants prior to sample collection. In vivo experiments with live vertebrates were performed according to protocol AVD11600202317157 approved by the Central Committee of Animal Experiments (The Hague, the Netherlands) and the Leiden University Animal Experimental Committee according to Dutch and European legislation (EU 2010/63/EU).
