Guo, Ying https://orcid.org/0000-0002-4423-113X
Sui, Pinpin https://orcid.org/0000-0003-3779-9592
Yang, Hui
Zhu, Ganqian
Li, Ying https://orcid.org/0000-0002-3308-906X
Chen, Shi
Zhao, Yuehui
Ge, Guo https://orcid.org/0000-0002-6362-772X
Eisa, Yusra A.
Delma, Caroline R.
Medina, Edward A. https://orcid.org/0000-0002-1305-4046
Zhang, Peng https://orcid.org/0000-0002-3394-6922
Lee, Jihoon https://orcid.org/0000-0002-4537-9638
Xu, Mingjiang https://orcid.org/0000-0002-7063-6253
Yang, Feng-Chun https://orcid.org/0000-0001-8524-4095
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (HL149318)
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (HL145883)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (CA172408)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (CA172408)
Article History
Received: 16 January 2025
Revised: 15 October 2025
Accepted: 25 November 2025
First Online: 26 January 2026
Competing interests
: The authors declare no competing interests.
: All experiments were performed in accordance with relevant guidelines and regulations. All animal experiments were conducted in accordance with the National Institutes of Health’s guidelines on animal care and use. Experiment protocols were approved by the Institutional Animal Care and Use Committee of the University of Texas Health Science Center at San Antonio. All animals received humane care in compliance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals (National Academies Press, 2011).