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Authors
Gonzales, Fanny https://orcid.org/0000-0003-1093-351X
Schneider, Constanze
Alexe, Gabriela https://orcid.org/0000-0002-5668-6297
Lin, Shan
Khalid, Delan
Alvarez, Montserrat
Basanthakumar, Allen https://orcid.org/0000-0001-7664-5030
Ellegast, Jana M.
Merickel, Lucy https://orcid.org/0009-0008-8858-2776
Salhotra, Silvi
Taillon, Audrey
Giaimo, Mariateresa https://orcid.org/0000-0002-8748-7012
Wunderlich, Mark
Ansari, Marc
Perry, Jennifer A.
Degar, Barbara
Pikman, Yana https://orcid.org/0000-0002-5336-0216
Stegmaier, Kimberly https://orcid.org/0000-0003-0218-7895
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Article History
Received: 25 April 2025
Revised: 5 November 2025
Accepted: 12 December 2025
First Online: 8 January 2026
Competing interests
: FG was supported with funding from the French National Cancer Institute and the ARC Foundation for Cancer Research. CS was supported by a Helen Gurley Brown Fellowship. CS and KS were supported with funding from The Selig Family Fund for Pediatric Cancer Research. JME received funding from the Rally Foundation for Childhood Cancer Research and the American Society of Hematology. SL was a Fellow of Blood Cancer United, formerly The Leukemia & Lymphoma Society and was supported by NCI R00 CA263161. MW was supported by NCI R50 CA211404. YP received support from CURE Childhood Cancer Foundation, Rally Foundation for Childhood Cancer Research, St. Baldrick’s Foundation and Hyundai Hope on Wheels. KS was supported by Blood Cancer United, formerly The Leukemia & Lymphoma Society, Rally Foundation for Childhood Cancer Research, Children’s Leukemia Research Association (CLRA), and a National Cancer Institute R35 CA283977. KS received grant funding from the DFCI/Novartis Drug Discovery Program and is a member of the SAB and has stock options with Auron Therapeutics on topics unrelated to this work. JME reports spousal employment at Novartis Pharma AG.
: All methods were performed in accordance with the relevant guidelines and regulations, including the Declaration of Helsinki. All animal experiments were approved by the DFCI Institutional Animal Care and Use Committee and conducted in accordance with institutional guidelines. Informed consent was obtained from all participants or their legal guardians prior to sample collection.
