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Authors
Chakraborty, Samarpana
Morganti, Claudia
Zaldana, Kimberly https://orcid.org/0009-0002-0300-5176
Rivera Pena, Bianca https://orcid.org/0000-0001-8821-0210
Zhang, Hui
Verma, Divij
Gitego, Nadege
Ma, Feiyang
Aluri, Srinivas
Pradhan, Kith
Gordon-Mitchell, Shanisha
Mantzaris, Ioannis
Goldfinger, Mendel
Feldman, Eric
Gritsman, Kira https://orcid.org/0000-0002-1367-1167
Shi, Yang
Hubner, Stefan
Qiu, Yi Hua
Brown, Brandon D.
Khasawneh, Abdullah
Skwarska, Anna
de Camargo Magalhães, Eduardo Sabino https://orcid.org/0000-0002-7726-4827
Verma, Amit
Konopleva, Marina https://orcid.org/0000-0002-9347-2212
Tabe, Yoko https://orcid.org/0000-0002-3734-0346
Gavathiotis, Evripidis https://orcid.org/0000-0001-6319-8331
Colla, Simona https://orcid.org/0000-0001-6583-8910
Gollob, Jared
Dey, Joyoti
Kornblau, Steven M. https://orcid.org/0000-0002-5990-9548
Koralov, Sergei B. https://orcid.org/0000-0002-4843-3791
Ito, Keisuke https://orcid.org/0000-0002-6702-9735
Shastri, Aditi https://orcid.org/0000-0002-5366-8288
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Funding
Funding for this research was provided by:
MDS Foundation Gilbert Bruce Smith grant, Kymera Therapeutics Research Grant, Leukemia Lymphoma Society TRP Grant
U.S. Department of Health & Human Services | NIH | National Cancer Institute
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Article History
Received: 11 August 2025
Revised: 5 December 2025
Accepted: 2 February 2026
First Online: 17 February 2026
Change Date: 25 February 2026
Change Type: Update
Change Details: The following information was missing from the Acknowledgement section: AS received funding support for the work from the MDS Foundation Young Investigator Award 2021 and Kymera Therapeutics Sponsored Research Agreement.
Competing interests
: SC received financial support from the Ceriale Postdoctoral Fellowship award. BRP was financially supported by the Einstein Aging Research Training Grant (T32): 5T32AG23475-22 and the Institutional Research and Academic Career Development Awards (IRACDA) Grant K12GM102779. DV was supported by K12CA279871 NCI career development award and Paul S. Frenette Scholar Award. KI is supported by NIH grants (R01DK098263, R01HL148852) and Blood Cancer United (8040-24). In the past 3 years AS has received reimbursement & honoraria for educational activities from PeerView, ACHL, Great Debates, HemeOnc Pulse, MJHS Lifesciences, VJ HemeOnc and Geron. Advisory board fees from Kymera Therapeutics, Geron, Ryvu Therapeutics, Caris Lifesciences. Research funding from Kymera Therapeutics and Ryvu Therapeutics and is on the Data Safety Monitoring Board for Servier Pharmaceuticals. A.V. has received research funding from BMS, Jannsen, MedPacto, Curis, Prelude, Halia and Ryvu, has received compensation as a scientific advisor to Stelexis Therapeutics, Calico and Aurigene and has equity ownership in Roshon, Stelexis and clinStreet. SBK had an SRA with Kymera Therapeutics. EG reports compensation for consulting and/or equity ownership from BaxGen Therapeutics, BeanPod Biosciences, Comorin Therapeutics, Life Biosciences, Stelexis Biosciences for projects unrelated to this work. MK is in the advisory board of AbbVie, Auxenion GmbH, Dark Blue Therapeutics, Legend Biotech, MEI Pharma, Menarini/Stemline Therapeutics, Novartis, Servier, Syndax, Vincerx and consulting for AbbVie, Adaptive, AmMax, AstraZeneca, Curis, Janssen, Kyowa Kirin, Menarini/Stemline Therapeutics, Mitsubishi Tanabe Pharma American, Sanofi Aventis, Servier. MK has received research funding from AbbVie, Janssen, Klondike Biopharma. KG received research funding from Ionctura, SA and ADC Therapeutics. IM reports participation in advisory board with Ascentage Pharma. AECOM Stem Cell Isolation and Xenotransplantation Facility is funded through New York Stem Cell Science grant no. C029154, Analytical Imaging Facility is funded through NCI cancer center support grant P30CA013330 and shared instrument grant JEOL 1400Plus TEM: SIG #1S10OD016214-01A1, Einstein FACS Core Facility is supported by NIH grants - P30CA013330 and shared instruments grants S10OD026833 and S10OD032169. We also acknowledge the availability of Leica Stellaris 8 Confocal Microscope (1S10OD034397-01) in the shared facility of Albert Einstein College of Medicine.
: All methods were performed in accordance with the relevant guidelines and regulations. Murine experiments were performed in accordance with the protocol (#00001526) approved by the Institutional Animal Care and Use Committee at Albert Einstein College of Medicine (AECOM). AML patient samples were obtained from an IRB approved biobank (#2005-536) at the Albert Einstein College of Medicine.
