Fascì, Amelia
Vallone, Francesco Edoardo
Nabelsi, Nahal
Viry, Elodie
Sana, Ilenia
Morabito, Alessia https://orcid.org/0009-0009-2313-6748
Seghezzi, Silvia https://orcid.org/0009-0007-7010-7072
Pesce, Noemi Anna
Rovere, Matteo
Bertola, Nadia
Duculty, Chloé
Ravera, Silvia
Mouhssine, Samir https://orcid.org/0000-0002-0389-3268
Muzio, Marta https://orcid.org/0000-0002-7761-759X
Ghia, Paolo https://orcid.org/0000-0003-3750-7342
Vitale, Candida https://orcid.org/0000-0002-2592-8724
Coscia, Marta
Moussay, Etienne https://orcid.org/0000-0002-0879-8067
Gaidano, Gianluca
Allan, John
Furman, Richard R. https://orcid.org/0000-0003-1677-7626
Paggetti, Jerome https://orcid.org/0000-0001-9460-5876
Vaisitti, Tiziana https://orcid.org/0000-0002-3375-6985
Deaglio, Silvia https://orcid.org/0000-0003-0632-5036
Funding for this research was provided by:
Associazione Italiana per la Ricerca sul Cancro (23095)
Associazione Italiana per la Ricerca sul Cancro (23107)
Associazione Italiana per la Ricerca sul Cancro (21198)
Fonds De La Recherche Scientifique - FNRS (7.4572.22)
Fonds National de la Recherche Luxembourg (C20/BM/14582635, and C20/BM/14592342, C23/BM/17987391 and C24/BM18920969)
Article History
Received: 8 September 2025
Revised: 9 February 2026
Accepted: 4 March 2026
First Online: 23 March 2026
Competing interests
: PG received honoraria from AbbVie, AstraZeneca, BeiGene, BMS, Galapagos, Johnson&Johnson, Lilly/Loxo Oncology, MSD, Roche and research funding from AbbVie, AstraZeneca, BeiGene, BMS, Johnson&Johnson, Lilly/Loxo Oncology, MSD.
: All methods were performed in accordance with relevant guidelines and regulations. Peripheral blood samples from CLL patients were obtained after informed consent, in accordance with Institutional Guidelines and the Declaration of Helsinki. The study was approved by the Institutional Review Board of the recruiting center (Prot. n. 0002013).