Zhou, Changli https://orcid.org/0000-0002-5984-4289
Bian, Sicheng https://orcid.org/0000-0001-9527-2102
Pang, Jiuxia
Bian, Huiqin
Cheng, Tao
Koyama, Hiroaki
Liu, Bin https://orcid.org/0000-0002-6581-780X
Li, Bing
Tse, William
Liu, Shujun https://orcid.org/0000-0002-5347-8345
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA248019)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA266256)
Article History
Received: 2 December 2025
Revised: 16 February 2026
Accepted: 12 March 2026
First Online: 10 April 2026
Competing interests
: The authors declare no competing interests.
: All patients gave their written informed consent for scientific evaluations. The current study was approved by the Institutional Review Board of the MetroHealth System and conducted in accordance with the Declaration of Helsinki. All animal experiments were approved by the Institutional Animal Care and Use Committees of the Case Western Reserve University and were in accordance with the U.S. National Institutes of Health (NIH) Guide for Care and Use of Laboratory Animals.