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Authors
Saida, Satoshi https://orcid.org/0000-0002-8930-3539
Toki, Tsutomu https://orcid.org/0000-0002-0061-9781
Shimizu, Ritsuko https://orcid.org/0000-0001-6672-7606
Hama, Asahito
Deguchi, Takao https://orcid.org/0000-0001-9932-4299
Yamato, Genki
Kanezaki, Rika
Iwamoto, Shotaro https://orcid.org/0000-0002-7710-2449
Morimoto, Mari
Hasegawa, Daisuke https://orcid.org/0000-0002-9446-9568
Ueda, Takahiro
Yokosuka, Tomoko
Suzuki, Kyogo https://orcid.org/0000-0001-8643-2987
Shimada, Akira
Hayashi, Yasuhide
Ito, Etsuro https://orcid.org/0000-0002-0168-2475
Watanabe, Kenichiro
Terui, Kiminori https://orcid.org/0000-0003-1294-8635
Muramatsu, Hideki https://orcid.org/0000-0002-8801-0021
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Funding
Funding for this research was provided by:
Japan Agency for Medical Research and Development (JP17ck0106381)
Japan Agency for Medical Research and Development (JP20ck0106435)
Japan Agency for Medical Research and Development (JP23ck0106677)
Japan Agency for Medical Research and Development (JP25ck0106936)
MEXT | Japan Society for the Promotion of Science (26860795)
Takeda Science Foundation
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Article History
Received: 23 October 2025
Revised: 24 February 2026
Accepted: 27 March 2026
First Online: 5 May 2026
Competing interests
: The authors declare no competing financial interests. Readers are welcome to comment on the online version of this study.
: The present study is a secondary analysis of the TAM-10 prospective observational cohort, in which patients were stratified by platelet count at diagnosis to evaluate clinical, inflammatory, and genetic features across the spectrum of platelet abnormalities. All methods were performed in accordance with the relevant guidelines and regulations. Written informed consent was obtained from parents or legal guardians prior to data and biological sample collection. The TAM-10 study was approved by the institutional review boards of all participating centers. This secondary analysis was conducted in accordance with the Declaration of Helsinki and received ethical approval from the Kyoto University Graduate School and Faculty of Medicine and the Kyoto University Hospital Ethics Committee.
