Tan, Jiaqi
He, Fuhong https://orcid.org/0000-0002-3176-8309
Hu, Haiyang https://orcid.org/0000-0002-6516-4095
Cao, Wenyue https://orcid.org/0000-0001-8718-6634
Wang, Na
Zuo, Xingxing
Huang, Liang https://orcid.org/0000-0002-8370-3232
Zhou, Jianfeng https://orcid.org/0000-0002-1332-9230
Wang, Qian-Fei https://orcid.org/0000-0002-0086-2626
Funding for this research was provided by:
CAS | Beijing Institute of Genomics, Chinese Academy of Sciences (XDA0460403)
National Natural Science Foundation of China (81970175)
National Natural Science Foundation of China (82200189)
Article History
Received: 30 September 2025
Revised: 24 March 2026
Accepted: 20 April 2026
First Online: 29 May 2026
Competing interests
: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
: This study was performed in accordance with the Declaration of Helsinki and written informed consent was obtained from each participant. Ethical approval was obtained from the Institutional Review Board of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. The clinical trial was registered in the Chinese Clinical Trial Registry with the number ChiCTR-OPN-16008526.