Teng, Teng
Clarke, Gerard https://orcid.org/0000-0001-9771-3979
Maes, Michael
Jiang, Yuanliang
Wang, Jun
Li, Xuemei
Yin, Bangmin
Xiang, Yajie
Fan, Li
Liu, Xueer
Wang, Jie
Liu, Shouhuan
Huang, Yunqing
Licinio, Julio https://orcid.org/0000-0001-6905-5884
Zhou, Xinyu https://orcid.org/0000-0003-1908-0357
Xie, Peng https://orcid.org/0000-0002-0081-6048
Article History
Received: 28 June 2021
Revised: 8 October 2021
Accepted: 14 October 2021
First Online: 1 November 2021
Competing interests
: The authors declare no competing interests.
: The experiment protocol was approved by the Ethics Committee of Chongqing Medical University (approval no.: 20180705) in accordance with the recommendations of the Weatherall report, “The use of NHP in research” [] and “Guide for the Care and Use of Laboratory Animals” []. We also followed nc3r recommendations () by using the minimum number of depressed macaques and age-matched controls and the sample sizes (<i>n</i> = 5/every group) of cynomolgus macaques were chosen []. The facilities, housing and primate laboratories used in this study are accredited by the Association for Assessment and Accreditation of Laboratory Animal Care. All subjects were housed in single cages (1.0 m × 1.5 m × 1.5 m, L × W × H) under a 12 h light/dark cycle (≥18 °C, 40–70% relative humidity), provided water ad libitum, and fed fresh fruits, vegetables and monkey chow twice daily.