Harding, Rebecca https://orcid.org/0009-0008-2701-6930
Singer, Neomi
Wall, Matthew B.
Hendler, Talma https://orcid.org/0000-0002-4182-4335
Erritzoe, David https://orcid.org/0000-0002-7022-6211
Nutt, David https://orcid.org/0000-0002-1286-1401
Carhart-Harris, Robin
Roseman, Leor
Funding for this research was provided by:
Supported by a private donation from the Alexander Mosley Charitable Trust and by the founding partners of Imperial College London’s Centre for Psychedelic Research.
Article History
Received: 11 January 2024
Revised: 26 March 2025
Accepted: 15 April 2025
First Online: 26 April 2025
Change Date: 6 June 2025
Change Type: Update
Change Details: The original online version of this article was revised: The following part of the abstract had a minor error: ‘Following PT, there was greater activation in the ventromedial prefrontal cortex and sensory regions, and reduced activation in the angular gyrus.’ This is now corrected to ‘Following PT, there was decreased activation in the ventromedial prefrontal cortex and angular gyrus, and greater activation in sensory regions.’ The original article has been updated accordingly.
Change Date: 6 June 2025
Change Type: Correction
Change Details: A Correction to this paper has been published:
Change Details: https://doi.org/10.1038/s41380-025-03066-1
Competing interests
: Prof Carhart-Harris reports receiving consulting fees from Mindstate and Entheos Labs. Dr. Erritzoe, receiving consulting fees from Mydecine, Entheon Biomedical, Clerkenwell Health, Smallpharma Ltd and Field Trip Health Ltd; and Prof Nutt, receiving fees from Algernon and H. Lundbeck and Beckley Psytech, advisory board fees from COMPASS Pathways and lecture fees from Takeda and Otsuka and Janssen plus owns stock in Alcarelle, and Psyched Wellness. Dr Wall’s primary employer is Invicro LLC, a contract research organisation that provides research services to the pharmaceutical and biotechnology industries. Rebecca Harding, Dr Neomi Singer and Dr Leor Roseman have nothing to declare.
: This study was approved by the Brent Research Ethics Committee, with additional approvals from the UK Medicines & Healthcare products Regulatory Agency, the Health Research Authority, and Imperial College London (Approval number: 17HH3790; clinicaltrials.gov: NCT03429075). All subjects gave written informed consent, and the trial was conducted under the principles of Good Clinical Practice.