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APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodegeneration (N), halting progressive ATN pathology in a preclinical model

Crossref DOI link: https://doi.org/10.1038/s41380-025-03036-7

Published Online: 2025-04-30

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Vanherle, Sarah https://orcid.org/0009-0008-1594-5521
Janssen, Art https://orcid.org/0000-0002-9499-5680
Gutiérrez de Ravé, Manuel https://orcid.org/0000-0001-8545-1166
Janssen, Bieke

Lodder, Chritica

Botella Lucena, Pablo

Kessels, Sofie https://orcid.org/0000-0002-0070-7482
Hardy, Jana https://orcid.org/0009-0000-7511-1782
Vandeput, Eline

Wang, Yanyan

Stancu, Ilie-Cosmin https://orcid.org/0000-0003-4271-0193
Segal, Andrei https://orcid.org/0000-0002-0981-9587
Kleinewietfeld, Markus

Voets, Thomas

Brône, Bert

Poovathingal, Suresh

Alpizar, Yeranddy A. https://orcid.org/0000-0003-1959-5393
Dewachter, Ilse https://orcid.org/0000-0001-7202-515X
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Text and Data Mining valid from 2025-04-30

Version of Record valid from 2025-04-30
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Article History

Received: 3 July 2024

Revised: 12 March 2025

Accepted: 15 April 2025

First Online: 30 April 2025

Competing interests

: The authors declare no competing interests.

: The ethical committee for animal welfare of Hasselt University approved all the performed experiments. All methods were performed in accordance with the relevant guidelines and regulations.

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